Motorists travelling on the M1 southbound between Junction 11 and Junction 10 should expect to experience delays of around 45 minutes and six miles of congestion.
The crash, which is believed to have happened at around 2:45pm on Tuesday, has caused three lanes to be shut on the M1.
Lanes one, two and three are shut near Luton, causing traffic to move much slower than usual.
National Highways reported around five miles of congestion and delays of up to 50 minutes.
The details and cause of the collision are yet to be revealed.
Police are on the scene investigating the circumstances of the incident.
The crash was first flagged on social media by National Highways.
In a tweet, they said: “Lanes 1, 2 and 3 are closed on the #M1 southbound between J11 and J10 near (#Luton) due to a collision. National Highways Traffic Officers are en-route.”
READ MORE: Pair ‘murdered Uber driver for taking them to the wrong nightclub’
It hasn’t been revealed how many cars were involved in the collision or whether there has been any serious injuries.
Lane 3 was reopened at around 3:30pm but lanes 1 and 2 remain closed.
Delays of 45 minutes remain above normal travel time and there is around six miles of congestion on the approach to the incident.
MORE TO FOLLOW..